1-Iodoalkynes are one type of the most reactive and the most practical intermediates in organic synthesis. Here, some facile and efficient methods for the 1-iodination of terminal alkynes are developed using N-iodosuccinimide (NIS) as an iodination reagent and some inexpensive mild bases as catalysts. K2CO3 and 4-dimethylaminopyridine (DMAP) have been proven to be the most suitable inorganic and organic bases, succeeding in 17 examples with excellent yields (up to 99%).
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Yang et al. (2024) studied this question.
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