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September 20, 2025British Journal of Haematology

Can we move beyond myeloablative conditioning (MAC)? A comparison of MAC versus reduced intensity conditioning (RIC) in patients aged younger than 65 years undergoing allogeneic haematopoietic cell transplantation using ATG‐PTCy‐CSA for GVHD prophylaxis

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Authors

RARuah AlyamanyAAAhmed AlnughmushMRMats Remberger

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Overview

Retrospective analysis shows no survival difference between MAC and RIC, suggesting MAC may enhance disease control.

Key Points

  • No significant difference in overall survival between MAC and RIC at 2 years post-transplant.
  • Relapse incidence was significantly higher in the RIC group, at 27.0%, compared to 16.1% in the MAC group.
  • This retrospective study used propensity score matching to assess outcomes in younger patients with a specific GVHD prophylaxis.
  • Findings indicate MAC's relevance for younger patients, highlighting a potential need for further prospective studies.

Cite This Study

Alyamany et al. (2025) studied this question.

synapsesocial.com/papers/68d46abb31b076d99fa67d73https://doi.org/10.1111/bjh.70170
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