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September 20, 2025Journal of Agricultural and Food Chemistry

A Novel Marine Bacterium-Derived Heparinase with High Potential for the Structure–Function Studies of Heparin/Heparan Sulfate

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Authors

XXXiangyu XuQZQingdong ZhangXCXiaoyu Cui

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Overview

Identifying a unique heparinase from marine sources, this study reveals its potential in analyzing heparin and heparan sulfate, indicating new avenues for structural studies.

Key Points

  • HD1492 demonstrates unique enzymatic properties, enabling deeper analysis of heparin/heparan sulfate structures.
  • The heparinase preferentially cleaves sulfated regions, generating resistant oligosaccharides that reveal new insights into glycosaminoglycan composition.
  • This research utilizes mouse organ-derived glycosaminoglycans to validate the heparinase's effectiveness, streamlining disaccharide analysis.
  • HD1492's capabilities distinguish it from terrestrial heparinases, providing a valuable tool for quality control in related products.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d46abb31b076d99fa67fe2https://doi.org/10.1021/acs.jafc.5c08686
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design Principle of Heparanase Inhibitors: A Combined In Vitro and In Silico Study2024 · 8 citations
  2. 2Systematic Virtual Screening of Heparan Sulfate Oligosaccharides and Mechanistic Insights into Heparanase Inhibition2026
  3. 3The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives2025 · 7 citations
  4. 4Enzymatic access to the rare ΔUA (1→4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control2024 · 1 citations
  5. 5Development of a sensitive and specific method to measure heparanase activity in complex biological matrices2026 · 2 citations