This method demonstrates efficient synthesis of spiroisoxazol-5(4H)-ones, highlighting stereospecificity and atomic economy.
A DBU-promoted (4 + 1)-annulation reaction between donor-acceptor (D-A) cyclopropanes and 3-phenylisoxazolone has been developed. Using this method, some valuable spiroisoxazol-5(4H)-one derivatives can be obtained easily in good yields. This protocol features producing highly stereospecific products, atomic economy, mild reaction conditions, and good efficiency, constituting an array of spiroisoxazol-5(4H)-ones.
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Cheng et al. (2025) studied this question.
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