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September 23, 2025Advances in Skin & Wound CareOpen Access

Use of Oral Antibiotics for Diabetic Foot Osteomyelitis: A Systematic Review

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Authors

SSSiddhartha SoodUniversity of TorontoRGRyan S.Q. GengUniversity of TorontoJWJihad WakedWestern University

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Implication

Systematic review evaluates oral antibiotics and intravenous antibiotics for diabetic foot osteomyelitis, suggesting effective therapies.

Key Points

  • Oral antibiotic therapy shows a complete resolution rate of 75.2% in diabetic foot osteomyelitis cases.
  • Total of 972 patients treated with oral antibiotics were analyzed across 26 unique studies, demonstrating significant efficacy.
  • Monotherapy and step-down therapy both displayed low recurrence rates of 5.4% and 3.9%, respectively, supporting oral therapy's reliability.
  • Oral antibiotics may offer crucial advantages in low-resource settings, enhancing patient ambulation and reducing hospitalization.

Cite This Study

Sood et al. (2025) studied this question.

synapsesocial.com/papers/68d4726431b076d99fa6b81ahttps://doi.org/10.1097/asw.0000000000000343
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral Antibiotics in the Management of Serious Neonatal Bacterial Infections in Developing Country Communities2008 · 46 citations
  2. 2Surgical management of a diabetic calcaneal ulceration and osteomyelitis with a partial calcanectomy and a sural neurofasciocutaneous flap2010 · 8 citations
  3. 3Ofloxacin versus parenteral therapy for chronic osteomyelitis1991 · 113 citations
  4. 4Oral Antibiotic Therapy for Osteomyelitis of the Foot in Diabetic Patients1985 · 12 citations
  5. 5Use of Tobramycin-Impregnated Calcium Sulphate Pellets in Addition to Oral Antibiotics2006 · 20 citations