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June 28, 2026JMIR Research ProtocolsOpen Access

Four-Week vs Six-Week Antibiotic Therapy in the Management of Nonsurgically Treated Diabetic Foot Osteomyelitis: Protocol for a Multicentric, Single-Blind Randomized Clinical Trial

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Authors

AGAmritava GhoshARAshu RastogiPSPranab Kumar Sahana

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Overview

Randomized trial evaluates remission rates of 4 vs 6 weeks of antibiotic therapy in diabetic foot osteomyelitis, indicating potential treatment optimization.

Key Points

  • The aim is to determine remission rates and adverse events for 4-week versus 6-week antibiotic therapy in nonsurgically treated diabetic foot osteomyelitis.
  • Single-blind randomized clinical trial with 52 participants in each group.
  • Participants randomized to receive either 4 or 6 weeks of antibiotic therapy based on current guidelines.
  • Assessment of remission and adverse events conducted at 6 months post-therapy.
  • Data collection began in December 2025 with 7 participants enrolled as of February 2026.
  • Expected publication of results is in the first quarter of 2029.

Cite This Study

Ghosh et al. (2026) studied this question.

synapsesocial.com/papers/6a40bae361bb0a67205c69a8https://doi.org/10.2196/93492
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P-909. Management of Diabetic Foot Osteomyelitis Following Surgical Intervention: Trends from an Academic Medical Center2026
  2. 2Variation in Systemic Antibiotic Treatment for Diabetic Foot Osteomyelitis in England and Wales: A Multi-Centre Case Review2024 · 7 citations
  3. 3Use of Oral Antibiotics for Diabetic Foot Osteomyelitis: A Systematic Review2025 · 2 citations
  4. 4Management and outcomes of people presenting with new diabetes-related foot infections: a prospective observational study from Australia and New Zealand2026
  5. 5Comparison of Oral Versus Intravenous Antibiotics for the Treatment of Diabetic Foot Osteomyelitis: A Propensity-Matched, Retrospective Cohort Study2026