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July 8, 2026Journal of the American Podiatric Medical AssociationOpen Access

Comparison of Oral Versus Intravenous Antibiotics for the Treatment of Diabetic Foot Osteomyelitis: A Propensity-Matched, Retrospective Cohort Study

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Authors

CTColin TkatchSBSteven BairAHAndrew J. Hale

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Overview

Retrospective cohort study compares antibiotic routes affecting treatment failure in diabetic foot osteomyelitis, suggesting no significant differences.

Key Points

  • This study aims to evaluate the impact of the route of antibiotic administration on treatment failure in patients with diabetic foot osteomyelitis.
  • Conducted a retrospective cohort study among patients with unresected diabetic foot osteomyelitis.
  • Matched treatment exposure groups using a propensity score.
  • Analyzed treatment failure defined as additional antibiotic use or surgical intervention within 1 year.
  • No significant difference in treatment failure rates between oral and intravenous groups (OR 0.98, 95% CI 0.30–3.19, p > 0.9).
  • Time-to-event analysis also showed no significant outcome disparities between groups (p = 0.3).

Cite This Study

Tkatch et al. (2026) studied this question.

synapsesocial.com/papers/6a4dea28d2ea289ef6283fb8https://doi.org/10.3390/japma116040047
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Retrospective Cohort Study From 2 Academic Medical Centers: Oral vs Intravenous Antibiotics for Diabetic Osteomyelitis.2025 · 3 citations
  2. 2Use of Oral Antibiotics for Diabetic Foot Osteomyelitis: A Systematic Review2025 · 2 citations
  3. 3297. Evaluation of Oral Versus Intravenous Beta Lactams for the Treatment of Osteomyelitis2026
  4. 4P-909. Management of Diabetic Foot Osteomyelitis Following Surgical Intervention: Trends from an Academic Medical Center2026
  5. 5Evaluating Clinical Outcomes in Children With Acute Osteomyelitis Treated With Intravenous Versus Oral Antimicrobial Therapy2026