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September 23, 2025Food & Nutrition ResearchOpen Access

Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study

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Authors

CSChristiane SchönAMAntje MickaDMDaniel B. Menzel

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Overview

Randomized double-blind study finds (6S)-5-MethylTHF-2Chol has higher bioavailability than folic acid, suggesting improved nutrient absorption.

Key Points

  • The bioavailability of (6S)-5-MethylTHF-2Chol is significantly higher compared to folic acid, enhancing its potential as a nutritional supplement.
  • Incremental area under the curve for (6S)-5-MethylTHF was 2.56-fold higher than folic acid, confirming superior absorption in the gut.
  • Utilizing a randomized double-blind design, the study assessed the pharmacokinetics of both folate sources following a single dose.
  • The findings highlight the benefits of (6S)-5-MethylTHF-2Chol in nutraceutical applications due to its solubility and stability.

Cite This Study

Schön et al. (2025) studied this question.

synapsesocial.com/papers/68d4759931b076d99fa6da00https://doi.org/10.29219/fnr.v69.12633
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