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September 23, 2025Saudi Journal of Pathology and MicrobiologyOpen Access

A Rare Recurrent Kaposi Sarcoma in an HIV-Seronegative Saudi Man: A Case Report and Literature Review

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Authors

NANaela Al-MogahedMTMaram Abdullah Taleb

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Overview

Case report reveals recurrence of kaposi sarcoma in a healthy man, suggesting HHV8 involvement.

Key Points

  • Kaposi sarcoma can recur in immunocompetent individuals, notably among HIV-seronegative patients.
  • Histopathologic examination confirmed a spindle cell lesion that was positively immunoreactive to HHV8.
  • The patient presented with a recurrent dusky brown nodular lesion on the thigh, indicating possible progression.
  • Assessment of HHV8 status is crucial even in individuals without HIV, highlighting its role in such cases.

Cite This Study

Al-Mogahed et al. (2025) studied this question.

synapsesocial.com/papers/68d475a031b076d99fa6dc45https://doi.org/10.36348/sjpm.2025.v10i06.002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gastrointestinal Kaposi Sarcoma: A Rare Case of an Isolated Rectal Lesion in an Immunocompetent HIV-Negative Patient2023
  2. 2A Case of Kaposi Sarcoma Misdiagnosed for 2 years: A Case Report.2025
  3. 3Submandibular nodal involvement as the initial presentation of HIV-negative Kaposi sarcoma: a case report2026
  4. 4Unusual Localization of AIDS-Related Kaposi’s Sarcoma in a Heterosexual Male during the COVID-19 Pandemic: A Case Report2024 · 3 citations
  5. 5Angiomatous Subtype of Penile Kaposi Sarcoma With Concurrent HIV-Negative Multicentric Castleman Disease: A Case Report2026