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Case report reveals recurrence of kaposi sarcoma in a healthy man, suggesting HHV8 involvement.
Introduction: Kaposi sarcoma is a well-recognized vascular lesion that primarily affects the skin, following the course of three stages; patch, plaque and nodules. It is strongly associated with human herpes virus 8 (HHV8) and Human immunodeficiency virus (HIV). Nevertheless, it is a rare presentation in immunocompetent individuals. Case presentation: A seronegative middle-aged Saudi man with history of nasal Kaposi sarcoma, presents with a recurrent dusky brown nodular lesion on the thigh. Histopathologic examination showed a spindle cell lesion with intervening slit-like vascular spaces that are immunoreactive to HHV8. Conclusion: Kaposi sarcoma can occur and recur in the setting of HIV-seronegative healthy individuals, whom they present with a nodular vascular skin lesion. We recommend the assessment of HHV8 status in such lesions, despite seronegative HIV status.
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Al-Mogahed et al. (2025) studied this question.
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