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April 22, 2026The Egyptian Journal of OtolaryngologyOpen Access

Submandibular nodal involvement as the initial presentation of HIV-negative Kaposi sarcoma: a case report

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Authors

MCMatteo CariaA. O. Ordine Mauriziano di TorinoBFB FabianoA. O. Ordine Mauriziano di TorinoPCPaola CampisiA. O. Ordine Mauriziano di Torino

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Implication

Case report reveals nodal Kaposi sarcoma in an HIV-negative individual, suggesting broader diagnostic considerations.

Key Points

  • This case report aims to highlight the unusual initial presentation of Kaposi sarcoma as cervical lymphadenopathy in an HIV-negative patient.
  • Case presentation of a 71-year-old HIV-negative man with submandibular lymphadenopathy.
  • Surgical excision was performed followed by histopathological and immunohistochemical analyses.
  • Full-body skin examination identified an additional KS lesion on the hallux.
  • Confirmed diagnosis of Kaposi sarcoma via histopathology and immunohistochemistry.
  • Initial presentation included painless submandibular lymphadenopathy, which is rare in immunocompetent individuals.
  • Highlights the need for awareness of atypical KS presentations in differential diagnoses.

Cite This Study

Caria et al. (2026) studied this question.

synapsesocial.com/papers/69e866416e0dea528ddeab24https://doi.org/10.1186/s43163-026-01083-7
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Primary Kaposi's Sarcoma of the Head and Neck1984 · 62 citations
  2. 2Kaposi's Sarcoma of the Head and Neck1970 · 29 citations
  3. 3Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma1994 · 5,744 citations