What question did this study set out to answer?

To describe an uncommon and rapidly progressive presentation of nodal Kaposi sarcoma presenting without characteristic cutaneous or mucocutaneous lesions in an individual with HIV.

August 19, 2026CureusOpen Access

Atypical Kaposi Sarcoma in HIV Infection with Predominant Nodal Involvement

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Authors

MBMaria Dioselina Ruiz BarreraUniversidad México Contemporáneo LSLuis Ernesto Heredia SantosMexican Social Security Institute MMMaria Alaciel Galvan MerlosMexican Social Security Institute

Discussion

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Implication

Case report reveals severe nodal Kaposi sarcoma lacking skin lesions in an HIV patient, highlighting the critical need for prompt biopsy.

Key Points

To describe an uncommon and rapidly progressive presentation of nodal Kaposi sarcoma presenting without characteristic cutaneous or mucocutaneous lesions in an individual with HIV.
Evaluated a 26-year-old antiretroviral therapy-naive male with newly diagnosed HIV presenting with fever, hemodynamic instability, severe cytopenias, and generalized lymphadenopathy.
Performed diagnostic imaging and an excisional inguinal lymph node biopsy evaluated by routine histopathology and HHV-8 immunohistochemistry.
Histopathological and immunohistochemical analysis of the lymph node confirmed Kaposi sarcoma via spindle-cell proliferation, vascular slit spaces, and nuclear positivity for HHV-8 latent nuclear antigen-1 (LNA-1).
No cutaneous or mucosal lesions were present throughout the disease course, and the patient died from acute respiratory failure prior to completing KS- and HIV-directed treatment.

Cite This Study

Barrera et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d6943 https://doi.org/10.7759/cureus.114648

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August 19, 2026CureusOpen Access

Atypical Kaposi Sarcoma in HIV Infection with Predominant Nodal Involvement

View Full Paper

Ask AI

Bookmark

Authors

MBMaria Dioselina Ruiz BarreraUniversidad México Contemporáneo LSLuis Ernesto Heredia SantosMexican Social Security Institute MMMaria Alaciel Galvan MerlosMexican Social Security Institute

Discussion

Member takes

Implication

Case report reveals severe nodal Kaposi sarcoma lacking skin lesions in an HIV patient, highlighting the critical need for prompt biopsy.

Key Points

To describe an uncommon and rapidly progressive presentation of nodal Kaposi sarcoma presenting without characteristic cutaneous or mucocutaneous lesions in an individual with HIV.
Evaluated a 26-year-old antiretroviral therapy-naive male with newly diagnosed HIV presenting with fever, hemodynamic instability, severe cytopenias, and generalized lymphadenopathy.
Performed diagnostic imaging and an excisional inguinal lymph node biopsy evaluated by routine histopathology and HHV-8 immunohistochemistry.
Histopathological and immunohistochemical analysis of the lymph node confirmed Kaposi sarcoma via spindle-cell proliferation, vascular slit spaces, and nuclear positivity for HHV-8 latent nuclear antigen-1 (LNA-1).
No cutaneous or mucosal lesions were present throughout the disease course, and the patient died from acute respiratory failure prior to completing KS- and HIV-directed treatment.

Cite This Study

Barrera et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d6943 https://doi.org/10.7759/cureus.114648

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