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September 23, 2025Synfacts

Regio- and Enantioselective C(sp2)−H meta-Borylation of α,α-Diarylcarboxamides by Ir-Bifunctional Catalysis

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Key Points

The method achieves regio- and enantioselective borylation of α,α-diarylcarboxamides, enhancing synthetic utility.
With an impressive yield of 90% reported for the borylation reaction, the efficiency underscores its potential.
Utilizing ir-bifunctional catalysis, the protocol effectively triggers remote C(sp2)−H activation with high selectivity.
The findings may enable further developments in catalyst design for complex organic molecule synthesis.

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Implication

This process demonstrates enantioselective meta-borylation of α,α-diarylcarboxamides, suggesting advances in remote C(sp2)−H activation.

Abstract

Keywords Ir catalyst - bifunctional ligand - remote C(sp2)−H activation - borylation

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Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68d4764731b076d99fa6e020 https://doi.org/10.1055/a-2680-9655

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