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Observational analysis shows that glutamine treatment improves motor activity in HIV patients, suggesting immune system benefits.
Glutamine content is decreased in HIV patients because of its increased metabolizing by cells of the immune system. The progression of HIV infection is associated with body weight loss in patients. This loss is aggravated by opportunistic infections associated with fever, anorexia, diarrhea and malabsorption and correlates with decreased glutamine content. Glutamine deficiency facilitates the initial immunity-mediated multiplication of HIV and may lead to perpetual (chronic) activation of the immune system even after the complete suppression of HIV. Treating HIV patients with glutamine preparations results in improved cenesthesia, decreased neurotoxic phenomena, and increased motor activity.
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Луфт et al. (2015) studied this question.
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