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September 24, 2025Journal of Agricultural and Food Chemistry

Design, Synthesis, and Biological Activity Studies of Flavonol Derivatives Containing Pyrazolamide Structure

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Authors

CHChunmei HuNanjing Agricultural UniversityYQYujiao QiuGuizhou UniversityDSDan ShenYancheng Institute of Technology

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Implication

This research demonstrates the antifungal potential of J13 against Phytophthora capsici, indicating new agriculture applications.

Key Points

  • J13 showed exceptional inhibition against Phytophthora capsici, achieving an EC50 of 6.29 μg/mL.
  • In vivo tests confirmed J13's curative and protective effects on chili leaves were superior to traditional fungicides.
  • Mitochondrial dysfunction was induced by J13, influencing membrane potential and succinate dehydrogenase activity.
  • The findings propose innovative strategies for developing environmentally friendly fungicides with manageable biosafety.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8548b2b6861e4c3e4c9https://doi.org/10.1021/acs.jafc.5c07095
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Also Consider

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