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October 2, 2025Journal of Agricultural and Food Chemistry

Design, Synthesis, and Biological Activity Evaluation of Flavonol Derivatives Containing Piperazine and Piperidine Thiourea

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Authors

YWYuhong WangHFHong FuHPHaotao Pu

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Overview

Evaluation of flavonol derivatives revealed significant inhibition of pathogenic fungi and bacteria, suggesting new strategies for plant disease management.

Key Points

  • Q23 inhibited Phytophthora capsici growth effectively with an EC50 of 6.68 μg/mL, outperforming azoxystrobin.
  • Q24 demonstrated strong activity against Xanthomonas axonopodis with an EC50 of 5.13 μg/mL, surpassing thiodiazole-copper.
  • Mechanistic studies showed Q23 disrupts hyphal integrity and induces lipid peroxidation in fungi.
  • Further analysis indicates Q24 can suppress biofilm formation and reduce enzyme activity, impacting bacterial virulence.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68de8eaeaa6cec72c69ea7fchttps://doi.org/10.1021/acs.jafc.5c08456
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Also Consider

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  1. 1Novel FlavonolDerivatives Bearing a 1,2,3,4-TetrahydroquinolineMoiety: Design, Synthesis, and Anti- <i>Phytophthora capsici</i> Activity2026
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  3. 3Design, Synthesis, Antifungal Activity, and Mechanism of Action of New Piperidine-4-carbohydrazide Derivatives Bearing a Quinazolinyl Moiety2024 · 31 citations
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  5. 5Novel 5-Sulfonyl-1,3,4-thiadiazole-Substituted Flavonoids as Potential Bactericides and Fungicides: Design, Synthesis, Three-Dimensional Quantitative Structure–Activity Relationship Studies2024 · 16 citations