Figure 6 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma

In vivo functional evaluation of FH FOLR1-CAR T cells in metastatic PDX model. A, Average radiance of pulmonary PDX OS9 disease measured over 180 days from tumor inoculation by tail vein in mice treated with FOLR1-CART vs. NT T cells. B, Kaplan–Meier survival curves of xenografts treated with NT or FOLR1-CAR T cells. n = 5 per group. Statistical difference in survival evaluated using Mantel–Cox log-rank test. C, Bioluminescence imaging of metastatic pulmonary PDX OS9 tumor injected by tail vein in mice treated with NT or FOLR1-CAR T cells. Radiance scale indicates progressive metastatic osteosarcoma from blue to red. *Day 20 images use a minimum radiance cutoff of 3e4 p/second/cm²/sr to show the presence of tumor engraftment prior to treatment. Minimum radiance cutoff of 3e6 p/second/cm²/sr used for posttreatment images to avoid noise created by excess radiance detected. X indicates death. D, day.