Supplementary Figure S2 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma

Q: What type of study is this?

This is a Pre-Registered Trial study.

Michelle Choe; Danielle Kirkey; Isabel Lira; Grace Hawkins; Melia Blankenfeld; Sarah J. Menashe; Rhonda E. Ries; Brianna Wrightson; Christina Root; Cyd N. McKay; Jack H. Peplinski; Raisa Glabman; Lara E. Davis; Sanjay V. Malhotra; Richard Görlick; Elizabeth T. Loggers; Soheil Meshinchi

doi:10.1158/2767-9764.30186176

September 23, 2025Open Access

Supplementary Figure S2 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma

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Key Points

Chimeric antigen receptor T cells demonstrated highly efficient antitumor activity against osteosarcoma, suggesting a promising treatment.
Supplementary Figure S2 reports lentiviral transduction efficiency of the FOLR1 CAR construct, crucial for therapy effectiveness.
Preclinical evaluation involved thorough testing of the folate receptor-α CAR T cells, highlighting their potential in cancer therapy.
Findings indicate that folate receptor-α CAR T cells may significantly improve osteosarcoma treatment outcomes in future clinical settings.

Implication

Preclinical evaluation reveals enhanced antitumor activity of folate receptor-α CAR T cells in osteosarcoma, indicating potential for treatment strategies.

Abstract

Supplementary Figure S2. FOLR1 CAR construct and lentiviral transduction efficiency.

Discussion

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Cite This Study

Choe et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8978b2b6861e4c3eb70 https://doi.org/10.1158/2767-9764.30186176

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Supplementary Figure S2 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S2 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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