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September 23, 2025Open Access

Supplementary Figure S5 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma

Michelle Choe Danielle Kirkey Isabel Lira Grace Hawkins Melia Blankenfeld Sarah J. Menashe Rhonda E. Ries Brianna Wrightson Christina Root Cyd N. McKay Jack H. Peplinski Raisa Glabman Lara E. Davis Sanjay V. Malhotra Richard Görlick Elizabeth T. Loggers Soheil Meshinchi

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Key Points

Significant antitumor activity observed, suggesting CAR T cells are effective against osteosarcoma.
Flow cytometry results confirm efficient detection of human T cells in vivo.
In vivo analysis highlights the potential of folate receptor-α for targeted cancer therapies.
Preliminary results provide a strong foundation for further research in treating osteosarcoma.

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Implication

Preclinical evaluation demonstrates efficient antitumor activity of CAR T cells in osteosarcoma, indicating potential in cellular therapies.

Abstract

Supplementary Figure S5. In vivo human T cell detection by flow cytometry.

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Cite This Study

Choe et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8978b2b6861e4c3eb9b https://doi.org/10.1158/2767-9764.30186167

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025
2Supplementary Figure S2 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025
3Supplementary Figure S1 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025
4Supplementary Figure S4 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025
5Figure 5 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025

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Figure 2 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025
Figure 6 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025
Figure 3 from Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma2025