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September 24, 2025World Journal of Clinical OncologyOpen Access

Overview of Yttrium-90 radioembolization for advanced hepatocellular carcinoma: Current status and future perspectives

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Authors

HYHaiyang YuState Grid Corporation of China (China)CXCheng XieJilin UniversityHCHong-Qiao CaiJilin University

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Implication

Radioembolization shows improved outcomes in advanced HCC, suggesting a growing role in treatment strategies.

Key Points

  • Radioembolization improved disease control rates in advanced hepatocellular carcinoma and downstaging for transplantation.
  • Landmark trials like SARAH and DOSISPHERE-01 reported comparable outcomes to systemic therapies such as sorafenib.
  • The method involves delivering yttrium-90 microspheres directly to tumors, sparing healthy liver tissue while managing side effects.
  • Emerging innovations in imaging and dosimetry standardization may enhance the application of radioembolization in clinical practice.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8ba8b2b6861e4c3f0c5https://doi.org/10.5306/wjco.v16.i9.109730
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