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July 12, 2025World Journal of Gastrointestinal Oncology

Yttrium-90 microsphere therapy for hepatocellular carcinoma: Clinical efficacy, mechanistic insights, and comparative therapeutic perspectives

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Authors

YZYuhang ZhuMWMingwei WangYJYan Jiao

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Overview

Review demonstrates improved survival rates and tumor response in hepatocellular carcinoma with yttrium-90 therapy, highlighting its advantages over conventional treatments.

Key Points

  • Yttrium-90 microsphere therapy significantly improves overall survival and progression-free survival in hepatocellular carcinoma patients.
  • Robust tumor response rates are observed, with manageable adverse events associated with yttrium-90 therapy.
  • Advanced dosimetric techniques enhance the therapy's precision, tailoring radiation delivery to individual tumor characteristics.
  • Comparative analyses indicate yttrium-90 therapy offers superior local tumor control and a safer profile compared to traditional treatments.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbeadhttps://doi.org/10.4251/wjgo.v17.i7.109379
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Overview of Yttrium-90 radioembolization for advanced hepatocellular carcinoma: Current status and future perspectives2025 · 4 citations
  2. 2Combination Immunotherapy and Yttrium-90 Radioembolization in Hepatocellular Carcinoma: Biological Rationale, Clinical Evidence, and Future Directions2026 · 1 citations
  3. 3Phase I/II, first-in-human study of yttrium-90 carbon microspheres in patients with unresectable hepatocellular carcinoma: Safety and early efficacy profiles.2026
  4. 4Y-90 Radioembolization in Hepatocellular Carcinoma: Expanding the Role of Interventional Oncology in Downstaging and Bridging to Liver Transplantation2026
  5. 5Harnessing yttrium-90 selective internal radiation therapy for primary hepatocellular carcinoma: Mechanisms of action and combination strategies2025