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December 20, 2025Deleted JournalOpen Access

Harnessing yttrium-90 selective internal radiation therapy for primary hepatocellular carcinoma: Mechanisms of action and combination strategies

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Authors

YCYue ChaiDXDanyang XuYZYang Zha

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Overview

This review highlights yttrium-90 SIRT's benefits in improving tumor response in primary hepatocellular carcinoma, suggesting enhanced outcomes through systemic therapy.

Key Points

  • To explore the mechanisms and clinical validation of yttrium-90 selective internal radiation therapy for primary hepatocellular carcinoma.
  • Review of the mechanistic foundations of yttrium-90 SIRT
  • Analysis of clinical evidence on its efficacy
  • Comparative assessment with transarterial chemoembolization
  • Discussion on emerging strategies and biomarker-guided regimens
  • Yttrium-90 SIRT enhances tumor response compared to conventional therapies
  • Demonstrates efficacy in downstaging tumors and improving safety profiles
  • Offers potential synergies with systemic therapies for advanced disease

Cite This Study

Chai et al. (2025) studied this question.

synapsesocial.com/papers/6945e9325151ab1219e4d5fahttps://doi.org/10.36922/arnm025290037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective Internal Radiation Therapy for Hepatocellular Malignancies: Existing Evidence and Advances2026
  2. 2Yttrium-90 ablative-selective internal radiation therapy for hepatocellular carcinoma in Chinese patients: a case series2026
  3. 3Selective Internal Radiation Therapy (SIRT) for Hepatocellular Carcinoma: Real-World Experience from a Tertiary Care Centre2026 · 1 citations
  4. 4Yttrium-90 microsphere therapy for hepatocellular carcinoma: Clinical efficacy, mechanistic insights, and comparative therapeutic perspectives2025 · 2 citations
  5. 5Advancements in selective internal radiotherapy: Efficacy, safety, and future directions2026 · 1 citations