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This is a Experimental Study study.

September 24, 2025Open Access

HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs

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Cross-neutralizing antibodies were elicited by HIV Env trimers in all immunized non-human primates, highlighting promising vaccine potential.
Monoclonal antibodies isolated from the NHPs effectively targeted HIV, cross-neutralizing various divergent clinical isolates.
High-resolution cryoEM analysis confirmed similar targeting of the Env trimer apex by these antibodies compared to human bNAbs.
The study suggests a significant step forward in understanding vaccination strategies against HIV and potential for effective antibody responses.

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Vaccination strategy generates broadly neutralizing antibodies targeting HIV Env, suggesting implications for effective vaccine design.

Guenaga et al. (2025) studied this question.

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