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August 22, 2025Science ImmunologyOpen Access

HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates

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Apex bnAb precursors were consistently induced with long HCDR3s, revealing potential for effective HIV vaccination.
The study found that both adjuvanted protein and mRNA lipid nanoparticle immunizations led to promising results in primates.
Using cryo–electron microscopy, structures of elicited precursors exhibited features from multiple Apex bnAbs, highlighting their complexity.
This achievement marks a significant milestone in HIV vaccine research, especially in the context of outbred primate models.

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Immunization with an engineered Env trimer produced Apex bnAb precursors in rhesus macaques, indicating a path to improved vaccines.

Krystal et al. (2025) studied this question.

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