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September 24, 2025Open Access

The acquisition of rmpADC can increase virulence of classical Klebsiella pneumoniae in the absence of other hypervirulence-associated genes

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Authors

SSStephen M. SalisburyTMTaryn A. MinerLKLeslie A. Kent

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Overview

Introduction of rmp genes raises virulence traits in cKp, suggesting complex interactions with hypervirulence.

Key Points

  • Acquisition of rmpADC increased virulence in classical Klebsiella pneumoniae strains.
  • Infection models revealed that hypermucoviscosity does not guarantee increased virulence.
  • Analysis showed that rmp genes influence virulence potential independent of sequence and capsule types.
  • Understanding rmp's role is crucial given the rise of drug-resistant Klebsiella pneumoniae strains.

Cite This Study

Salisbury et al. (2025) studied this question.

synapsesocial.com/papers/68d6e14f8b2b6861e4c3fd8dhttps://doi.org/10.1101/2025.09.20.677538
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