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July 29, 2026Journal of BacteriologyOpen Access

Hypermucoviscosity in Klebsiella pneumoniae : manifestation, regulation, and roles in pathogenesis

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Authors

TDTamal DeyMSManoharan Shankar

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Overview

Review highlights how hypermucoviscosity enhances virulence in Klebsiella pneumoniae, indicating public health implications.

Key Points

  • This review aims to synthesize recent findings about hypermucoviscosity in Klebsiella pneumoniae, focusing on its regulation and impact on pathogenesis.
  • Review of recent literature on hypermucoviscosity and its role in Klebsiella pneumoniae infections.
  • Analysis of molecular mechanisms and regulatory controls associated with hypermucoviscosity.
  • Discussion of environmental factors influencing virulence traits.
  • Hypermucoviscosity is driven by increased capsular polysaccharide chain length and uniformity, not just production.
  • Non-hypervirulent lineages can gain virulence by acquiring mutations in the wzc gene, enhancing their ability to thrive.
  • Hypermucoviscosity hinders adhesion to epithelial cells but aids in immune evasion and systemic spread, showcasing niche-specific advantages.

Cite This Study

Dey et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2a3c8da07d9defa64ddhttps://doi.org/10.1128/jb.00123-26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microaerobic-mediated suppression of Klebsiella pneumoniae mucoviscosity is restored by rmpD overexpression2024 · 6 citations
  2. 2Wzc mutation enhances virulence in CRKP ST11-KL64 via complement-mediated lysis and lipopolysaccharide release2026 · 1 citations
  3. 3Klebsiella pneumoniae Liver Abscess Associated With Septic Endophthalmitis1986 · 553 citations
  4. 4Escherichia coli RcsA, a Positive Activator of Colanic Acid Capsular Polysaccharide Synthesis, Functions To Activate Its Own Expression1999 · 104 citations
  5. 5Genomic epidemiology and temperature dependency of hypermucoviscous Klebsiella pneumoniae in Japan2022 · 25 citations