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July 31, 2024Journal of Applied MicrobiologyOpen Access

Microaerobic-mediated suppression of Klebsiella pneumoniae mucoviscosity is restored by rmpD overexpression

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Authors

WSWangnan SunCRChengbo RongLCLiang Chen

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Overview

Laboratory analysis demonstrates microaerobic suppression of hypermucoviscosity in Klebsiella pneumoniae, indicating oxygen availability regulates virulence phenotypes.

Key Points

  • Microaerobic environment conditions suppress the hypermucoviscosity phenotype in hypervirulent Klebsiella pneumoniae, but this trait is restored by rmpD overexpression.
  • Investigation of microaerobic environment availability reveals environmental oxygen modulation of mucoviscosity, which defines the invasive potential of bacterial isolates.
  • These findings highlight oxygen availability as an external regulator of hypermucoviscosity in Klebsiella pneumoniae; cell-based preclinical validation remains necessary.

Cite This Study

Sun et al. (2024) studied this question.

synapsesocial.com/papers/68e5e3e6b6db6435875785d3https://doi.org/10.1093/jambio/lxae192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypermucoviscosity in <i>Klebsiella pneumoniae</i> : manifestation, regulation, and roles in pathogenesis2026
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  3. 3The acquisition of <i>rmpADC</i> can increase virulence of classical <i>Klebsiella pneumoniae</i> in the absence of other hypervirulence-associated genes2025
  4. 4The acquisition of <i>rmpADC can</i> increase virulence of classical <i>Klebsiella pneumoniae</i> in the absence of other hypervirulence-associated genes2025
  5. 5Phenotypic and genotypic analysis of hypermucoviscous Klebsiella pneumoniae (hmkp) strain2025