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December 9, 2025mBioOpen Access

The acquisition of rmpADC can increase virulence of classical Klebsiella pneumoniae in the absence of other hypervirulence-associated genes

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Authors

SSStephen M. SalisburyTMTaryn A. MinerLKLeslie A. Kent

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Overview

This study reveals increased virulence in antibiotic-resistant classical Klebsiella pneumoniae, suggesting rmpADC is a key factor.

Key Points

  • To determine the impact of the rmpADC operon on the virulence of classical Klebsiella pneumoniae strains.
  • Introduced rmp loci into classical Klebsiella pneumoniae isolates
  • Evaluated changes in hyromucoviscosity and virulence in a mouse model
  • Assessed the association between sequence type, capsule type, and virulence outcomes
  • Many isolates became HMV positive after rmp acquisition
  • Only a subset showed increased virulence in mouse models
  • Hypermucoviscosity was necessary but not sufficient for hypervirulence

Cite This Study

Salisbury et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8eb7https://doi.org/10.1128/mbio.03122-25
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