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September 27, 2025The Journal of PhysiologyOpen Access

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

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Authors

BMBeatrice MoscoloniCBCameron BeecheJCJulio A. Chirinos

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Overview

This analysis reveals sex dimorphism in cardiac anatomy among individuals, suggesting important clinical implications.

Key Points

  • Sex differences account for at least 25% of natural variation in heart structure, even when controlling for confounders.
  • Our statistical shape modelling approach captures subtle anatomical distinctions between male and female hearts.
  • Female hearts show consistently smaller chambers and different inter-chamber positioning compared to male hearts.
  • Understanding these anatomical differences is crucial for improving diagnosis and treatment of heart disease.

Cite This Study

Moscoloni et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3d4eebfec0fc523636bhttps://doi.org/10.1113/jp288667
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unveiling sex dimorphism in the healthy cardiac anatomy: fundamental differences between male and female heart shapes2025 · 1 citations
  2. 2Sex-specific shape models to disentangle sex effects and age-associated anatomical variation in biventricular cardiac anatomy2026
  3. 3Assessing the importance of sex and disease-specific anatomy in electrophysiology and mechanical simulations with a newly developed public virtual cohort of four-chamber heart models2026
  4. 4The female human heart at rest and during exercise: A review2014 · 19 citations
  5. 5Cardiovascular sex-differences: insights via physiology-based modeling and potential for noninvasive sensing via ballistocardiography2023 · 18 citations