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October 13, 2025Open Access

Unveiling sex dimorphism in the healthy cardiac anatomy: fundamental differences between male and female heart shapes

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Authors

BMBeatrice MoscoloniCBCameron BeecheJCJulio A. Chirinos

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Overview

Statistical shape modeling reveals significant variances in cardiac anatomy between sexes, suggesting differing health risks.

Key Points

  • Sex accounts for at least 25 percent of variability in cardiac morphology, indicating essential anatomical differences.
  • Discriminative metrics show strong classification between male and female heart shapes, with AUC values ranging from 0.96 to 0.71.
  • The study analyzed cardiac anatomy in a healthy subset of 456 individuals using statistical shape modeling and multivariate analysis.
  • Results emphasize the clinical importance of recognizing sex-specific differences for tailored cardiovascular assessments.

Cite This Study

Moscoloni et al. (2025) studied this question.

synapsesocial.com/papers/68ecc715d1cc7436f7d18987https://doi.org/10.48550/arxiv.2503.00197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes2025 · 4 citations
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  4. 4Cardiovascular sex-differences: insights via physiology-based modeling and potential for noninvasive sensing via ballistocardiography2023 · 18 citations
  5. 5The female human heart at rest and during exercise: A review2014 · 20 citations