New Markers for Determining the Severity of Intoxication in Patients with Complicated Forms of Acute Appendicitis

Background. Acute destructive appendicitis has been and remains the most important factor in the mortality structure of surgical patients with bacterial abdominal infection. Among the factors significant for diagnostics are the severity of intoxication The markers include the iron-containing protein lactoferrin (LF) and its positively charged fragment, lactoferricin (LFC). The Aim of Study. To study the relationship between serum levels of LF and LFC and the severity of endotoxicosis in patients with various forms of acute destructive appendicitis. Material and Methods. In blood serum samples of 45 patients with destructive forms of appendicitis of varying severity after laparoscopic or laparotomic The concentrations of Lf protein and Lfc peptide were studied after appendectomy. Results. When studying the levels of LF and LFC in patients with acute destructive appendicitis, it was found that their levels differ from the figures in donors by 3 times for both LF and LFC. Conclusion. 1. In acute complicated appendicitis, including that complicated by peritonitis, a statistically significant increase in the concentration of lactoferrin protein and lactoferricin peptide relative to the norm is observed in the blood serum, and in peritoneal exudate. 2. In patients with acute destructive appendicitis, lactoferrin levels in peritoneal exudate statistically significantly exceed serum levels of the same patients by 3–4 times, and lactoferricin levels in parallel samples do not differ from each other. 3. According to the data obtained in the work, the levels of LF and LFC after laparoscopic appendectomy are not statistically significantly different from levels after laparotomy appendectomy and depend only on the severity of the patient’s condition.