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September 27, 2025Frontiers in ImmunologyOpen Access

The half-century odyssey of regulatory B cells: from Breg discovery to emerging frontiers

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Authors

EZElina A. ZheremyanNKNikolai R. KonAUAlina S. Ustiugova

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Overview

This review traces the journey of regulatory B cells (Bregs), highlighting their dual role as immunomodulators and therapeutic targets.

Key Points

  • The study reveals the profound impact of regulatory B cells in maintaining immune balance and their key role in immunosuppression.
  • Key milestones in Breg research include the formal introduction of the term 'regulatory B cells' in the early 2000s and identification of various Breg subsets.
  • The review incorporates advances in single-cell multi-omics and novel marker identification, emphasizing techniques that enhance understanding of Bregs.
  • Future directions include exploring Breg-based therapeutic strategies, pointing to the clinical potential and challenges in this emerging field.

Cite This Study

Zheremyan et al. (2025) studied this question.

synapsesocial.com/papers/68d7be5eeebfec0fc523778ahttps://doi.org/10.3389/fimmu.2025.1681082
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