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June 28, 2026Immunotherapy AdvancesOpen Access

Harnessing the Duality of Regulatory B Cells: From Identification of Characteristic Molecules to Therapeutic Targeting

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Authors

LWLuman WangRLRonghua LiuYCYiwei Chu

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Overview

Comprehensive synthesis evaluates regulatory B cells' dual role in immune homeostasis and disease, suggesting therapeutic implications.

Key Points

  • This work aims to explore the dual role of regulatory B cells in immune function and their modulation by various factors.
  • Examined the interactions between Bregs and their microenvironment across different disease states.
  • Synthesized recent research on the roles of Bregs in autoimmunity, cancer, and allergies.
  • Bregs can suppress inflammation or promote disease progression based on their environmental cues.
  • Understanding Breg functionality is essential for developing tools and therapies that target these cells in different contexts.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba8861bb0a67205c66d4https://doi.org/10.1093/immadv/ltag011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity2026
  2. 2The half-century odyssey of regulatory B cells: from Breg discovery to emerging frontiers2025 · 8 citations
  3. 3Regulatory B-cells: immunomodulating mechanisms and important cellular targets underlining immunotherapy by immunoregulation2024
  4. 4Regulatory B Cells in Tumor Microenvironment2026 · 2 citations
  5. 5Regulatory B cells in the central nervous system: From immune regulation to neuroprotection2026