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September 27, 2025International Journal of Innovative Technologies in Social ScienceOpen Access

The Impact of Hyperuricemia on Cardiovascular Risk. Review of the Existing Literature

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Authors

MBMateusz Biszewski1 Military Clinical Hospital with Outpatient ClinicIDIda DunderCardinal Stefan Wyszyński University in WarsawEBElżbieta BebryszCardinal Stefan Wyszyński University in Warsaw

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Overview

Review reveals a link between hyperuricemia and cardiovascular mortality, suggesting SGLT2 inhibitors may improve outcomes.

Key Points

  • Hyperuricemia significantly increases the risk of cardiovascular mortality, with levels above 5 mg/dl linked to higher risks.
  • Evidence from randomized controlled trials and meta-analyses consistently shows that hyperuricemia correlates with higher all-cause mortality.
  • SGLT2 inhibitors not only lower uric acid levels but also enhance cardiovascular protection compared to traditional xanthine oxidase inhibitors.
  • Further research is needed to explore the impact of hyperuricemia on cardiovascular outcomes beyond existing studies.

Cite This Study

Biszewski et al. (2025) studied this question.

synapsesocial.com/papers/68d7be66eebfec0fc5237f25https://doi.org/10.31435/ijitss.3(47).2025.3778
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urate-Lowering Therapy in Cardiovascular Pharmacotherapy: From Mendelian Randomization Data to Cardio–Renal–Metabolic Risk Modulation2026 · 1 citations
  2. 2Hyperuricemia as an Early Indicator of Cardiovascular Risk in the General Population2025
  3. 3Hyperuricemia as an Early Indicator of Cardiovascular Risk in the General Population2025
  4. 4The Impact of Hyperuricemia on the Progression of Atherosclerotic Cardiovascular Disease2025
  5. 5Uric Acid and Cardiovascular Disease2026