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November 8, 2025Journal of Clinical MedicineOpen Access

Hyperuricemia as an Early Indicator of Cardiovascular Risk in the General Population

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Authors

FAFady Al-AzemCarl von Ossietzky Universität OldenburgBSBastian SchraderJSJoachim Schrader

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Overview

Prospective cohort study shows hyperuricemia raises incidence of cardiovascular events in patients with metabolic risk factors, indicating its potential as an early risk marker.

Key Points

  • This research aims to assess the correlation between hyperuricemia and cardiovascular risk in the general population.
  • Prospective cohort study design with 4082 participants
  • Divided into groups based on serum uric acid levels
  • Evaluated incidence of cardiovascular events and associated risk factors
  • Higher incidence of coronary artery disease (8.4% vs. 3.3%) among participants with elevated uric acid
  • Increased stroke incidence (2.6% vs. 1.2%) in those with hyperuricemia
  • Heart failure incidence was 3.4% in high uric acid group compared to 0.9%
  • Chronic kidney insufficiency was 4.5% vs. 1.9% for normal levels
  • Participants with hyperuricemia had more established risk factors like hypertension, obesity, and diabetes.

Cite This Study

Al-Azem et al. (2025) studied this question.

synapsesocial.com/papers/69253a35c0ce034ddc357c2fhttps://doi.org/10.3390/jcm14227922
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyperuricemia as an Early Indicator of Cardiovascular Risk in the General Population2025 · 1 citations
  2. 2Uric Acid and Cardiovascular Disease2026
  3. 3THE IMPACT OF HYPERURICEMIA ON CARDIOVASCULAR RISK. REVIEW OF THE EXISTING LITERATURE2025
  4. 4The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction2014 · 12 citations
  5. 5The Impact of Hyperuricemia on the Progression of Atherosclerotic Cardiovascular Disease2025