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September 27, 2025Scientific ReportsOpen Access

Integrative transcriptomic and metabolomic analysis explores mechanisms by which Astragalus membranaceus and Salvia miltiorrhiza ameliorates hypertensive renal damage

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Authors

WLWenpeng LiuCHCong HanWXWanli Xu

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Overview

Analysis demonstrates improvement of hypertensive renal damage in spontaneously hypertensive rats, highlighting metabolic processes and target genes.

Key Points

  • Astragalus membranaceus and Salvia miltiorrhiza significantly reduced blood pressure and improved renal function.
  • A total of 596 target mRNAs related to hypertensive renal damage were identified.
  • Transcriptional and metabolic analyses revealed co-enriched pathways linked to renal health.
  • Key metabolites were predominantly involved in linoleic acid and cholesterol metabolism pathways.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d7e84439bbb06045426cf1https://doi.org/10.1038/s41598-025-18241-1
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