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September 26, 2025HLA

The Novel Allele, HLA‐DQA1*03:80, With a Non‐Synonymous Mutation in Exon 3

Diamanto Kouniaki Smaro Aritzaki Alexandra Tsirogianni

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Key Points

The allele HLA-DQA1*03:80 exhibits a significant mutation, which could impact its function.
A single nucleotide change occurs at codon 134, where GGT is replaced by CGT.
This mutation is located in exon 3, emphasizing its relevance in allele expression.
Determining the implications of this nonsynonymous mutation may advance genetic understanding.

Implication

Analysis reveals a nucleotide substitution in codon 134 of HLA-DQA1*03:80 allele, highlighting possible genetic implications.

Abstract

The HLA‐DQA1*03:80 allele contains a single nucleotide substitution in codon 134 (GGT to CGT).

Discussion

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Cite This Study

Kouniaki et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0141e1c178a14f5e48 https://doi.org/10.1111/tan.70415

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Identification of the Novel Allele, <i>HLA‐DQB1*03:577</i> , by Next‐Generation Sequencing2025
2Characterisation of the Novel <i>HLA‐DQA1*03:02:05</i> Allele by Next‐Generation Sequencing2025 · 2 citations
3The Novel Allele, <i>HLA‐DPA1*01:213</i> , With a Non‐Synonymous Mutation in Exon 3Original Research · 2026 · 2 citations
4<i>HLA‐DQA1*01:181N</i> , a Novel HLA‐DQA1 Allele Identified by Next‐Generation Sequencingother · 2026 · 2 citations
5Identification of the Novel <scp>HLA</scp> Allele <i>HLA‐DQA1*03:90</i> by Next‐Generation SequencingOriginal Research · 2026

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Detection of the novel <i>HLA‐DQA1*05:73</i> allele with an amino acid substitution in the α2 extracellular domain2024

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