Chronic Liver Disease in Women and Its Clinical Profile - A Hospital Based Study.

Background: Chronic liver disease (CLD) is a major cause of morbidity and mortality worldwide. In women, the etiological spectrum and clinical profile differ from men due to hormonal, metabolic and autoimmune influences. Data on female-specific CLD patterns in India remain limited. To evaluate the clinical and etiological profil Objectives: e of CLD in women. Methods: This cross-sectional observational study was conducted in the Department of General Medicine at Government Medical College, Chhatrapati Sambhajinagar, Maharashtra, from January to June 2025. A total of 41 adult female patients with CLD were included. Clinical history, risk factors, examination findings, laboratory investigations, imaging and endoscopic evaluation were recorded. Severity was assessed using the Child–Turcotte–Pugh (CTP) classification. Data were analyzed as frequencies, percentages and means. Results: The mean age of patients was 36.8 ± 11.6 years, with the majority in the 30–39 years (31.7%) and 40–49 years (31.7%) age groups. Common risk factors included obesity (34.1%), diabetes mellitus (26.8%) and metabolic syndrome (24.4%). Abdominal distension (80.5%), anorexia (65.9%), jaundice (58.5%) and pedal edema (53.7%) were the predominant symptoms. The leading etiologies were NAFLD/NASH (22.0%), hepatitis C (17.1%), cryptogenic (17.1%) and hepatitis B (14.6%), while alcoholic liver disease was rare (4.9%). Splenomegaly (43.9%) and spider angioma (29.3%) were common signs. Most patients were in CTP Class B (51.2%) or C (41.5%). Major complications included ascites (68.3%), coagulopathy (43.9%) and variceal bleeding (29.3%). CLD in women in the present study most commonly presented in the repr Conclusion: oductive and perimenopausal age groups (30–49 years). Metabolic, viral and autoimmune etiologies predominate, while alcohol contributes minimally. Early screening and gender-focused preventive strategies are essential to reduce disease burden.