September 28, 2025MathematicsOpen Access

Subset Selection with Curtailment Among Treatments with Two Binary Endpoints in Comparison with a Control

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Sequential method identifies superior treatments over control using binary endpoints, highlighting efficiency gains.

The proposed procedure ensures a subset of superior treatments is selected over a control group, maintaining accuracy regardless of sample size.
With correct sampling and decision rules, the new method shows consistent probability of selection when shifting from fixed to adaptive designs.
Utilizing bivariate binomial and multinomial distributions, the method accommodates both independent and dependent endpoints in clinical trials.
Evaluations demonstrate notable sample size savings compared to traditional fixed-sample approaches, benefiting trial designs across three scenarios.

Yin et al. (2025) studied this question.

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