What question did this study set out to answer?

The aim is to create a cost function model to optimize clinical trial design for selecting between two treatments.

A Model for Selecting One of Two Medical Treatments

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial designs optimal treatment selection for patients, indicating cost-efficient decision-making strategies.

The aim is to create a cost function model to optimize clinical trial design for selecting between two treatments.
Developed a cost function with a focus on treatment consequences.
Analyzed fixed sample sizes and sequential trial designs.
Applied minimax, maximin, and Bayesian approaches for trial optimization.
Identified optimal sample sizes for fixed trials and boundary positions for sequential trials.
Conducted comparisons of costs and results across different trial approaches.

Theodore Colton (1963) studied this question.

View Full Paper

Ask AI

Bookmark