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September 29, 2025Trends in Sciences

N-2 Polyphenol Targets Vascular Calcium Channels to Exert Antihypertensive Effects: In Vitro and In Vivo Evaluation

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Authors

AKA.R. KhasanovIAIzzatullo AbdullaevSKShokhida Kadirova

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Overview

In vitro and in vivo analysis shows N-2 polyphenol's antihypertensive effects, indicating unique mechanisms involving calcium channels and endothelium.

Key Points

  • N-2 polyphenol lowered systolic pressure to 74.7 ± 3.3 mmHg, demonstrating strong antihypertensive potential in vivo.
  • In vitro, N-2 polyphenol inhibited Ca2+ influx through L-type calcium channels by 86.2 ± 2.4% at 50 μM concentration.
  • Study utilized both in vitro assays on vascular smooth muscle cells and in vivo models to assess N-2's dual mechanisms.
  • Results highlight N-2 polyphenol's promise as a candidate for managing hypertension through calcium channel blockade.

Cite This Study

Khasanov et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd1144ahttps://doi.org/10.48048/tis.2026.10782
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  3. 3Calcium Entry Blockade and Agonist-Mediated Vasoconstriction in Hypertensive Patients1990 · 1 citations
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