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December 1, 1981Clinical Science

Calcium Antagonists Decrease Adrenal and Vascular Responsiveness to Angiotensin II in Normal Man

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Why the study?

Does nifedipine reduce the pressor and aldosterone responses to angiotensin II in normal subjects?

Population

6 normal subjects

Comparison

Nifedipine 20 mg oral, given 30 minutes before… vs Baseline response to angiotensin II infusions…

Design

Other

Authors

JMJ. A. MillarCurtin UniversityKMKathleen McLeanChildren's NationalJRJL ReidThe University of Sydney

Discussion

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Overview

Nifedipine effects in normals support mechanistic inquiry; leaves open relevance to hypertension or practice.

Structured PICO

Does nifedipine reduce the pressor and aldosterone responses to angiotensin II in normal subjects?

P
Population
6 normal subjects
I
Intervention
Nifedipine 20 mg oral, given 30 minutes before angiotensin II infusions (5, 10, and 20 ng/min/kg)
C
Comparator
Baseline response to angiotensin II infusions without nifedipine (paired consecutive infusions)
O
Outcome
Pressor and aldosterone responses to angiotensin IIsurrogate

Nifedipine attenuates both the vascular pressor and adrenal aldosterone responses to angiotensin II, suggesting calcium channel blockers lower blood pressure through multiple mechanisms.

Cite This Study

Millar et al. (1981) studied this question.

synapsesocial.com/papers/6a7d3df545db7d096f6e4ab3https://doi.org/10.1042/cs061065s
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypotensive Action and Increased Plasma Renin Activity by Ca2+ Antagonist (Nifedipine) in Hypertensive Patients1976 · 93 citations
  2. 2Acute and Chronic Effects of Nifedipine on Plasma Renin Activity and Plasma Adrenaline and Noradrenaline in Controls and Hypertensive Patients1979 · 47 citations
  3. 3Hemodynamic and reflex responses to acute and chronic antihypertensive therapy with the calcium entry blocker nifedipine.1983 · 133 citations
  4. 4Effects of Calcium Antagonists and Nitroglycerin on Atrial Natriuretic Peptide in Normal Subjects and Patients with Essential Hypertension1989 · 12 citations
  5. 5Studies on the Natriuretic Effect of Nifedipine in Hypertensive Patients: Increase in Levels of Plasma Atrial Natriuretic Factor Without Participation of the Renal Kallikrein-Kinin System1987 · 16 citations