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September 30, 2025JAMA Neurology

Menopause Impact on Multiple Sclerosis Disability Progression

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Authors

FBFrancesca BridgePSPaul G. SanfilippoCZChao Zhu

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Overview

Cohort study shows no link between menopause and disability progression in women with multiple sclerosis, suggesting stability in disease trajectory.

Key Points

  • Menopause did not increase the risk of confirmed disability progression in women with MS.
  • The study included 987 women with relapse-onset MS, using data from the MSBase Registry.
  • Cox proportional hazards models adjusted for clinical factors indicated no significant change post-menopause.
  • These findings imply that menopause may not play a critical role in MS-related disability progression.

Cite This Study

Bridge et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e308a7d58c25ebb15dfhttps://doi.org/10.1001/jamaneurol.2025.3538
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Menopause and ageing in women with multiple sclerosis2026
  2. 2A proof-of-concept study on the relationship between lifetime Estrogen exposure, menopausal transition, and neurodegeneration in women with multiple sclerosis2026
  3. 3Sex differences in relapse-independent and relapse-associated disability progression in relapsing-remitting multiple sclerosis: a real-world inverse-probability weighted study2025 · 3 citations
  4. 4Long-Term Disability Outcomes in Relapsing–Remitting Multiple Sclerosis Patients: Impact of Clinical and Demographic Factors on Disease Progression2024 · 7 citations
  5. 5Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability2025