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March 6, 2026Journal of the Neurological SciencesOpen Access

A proof-of-concept study on the relationship between lifetime Estrogen exposure, menopausal transition, and neurodegeneration in women with multiple sclerosis

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Authors

AIAntonio IannielloCPClaudia PiervincenziCPCarlo Pozzilli

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Overview

This proof-of-concept study reveals hormonal influences on disease outcomes in women with multiple sclerosis, suggesting important links.

Key Points

  • The study aims to investigate the correlation between lifetime estrogen exposure and disease outcomes in women with multiple sclerosis during menopause.
  • Conducted a two-phase study with thirty-two perimenopausal women with multiple sclerosis.
  • Calculated cumulative lifetime estrogen exposure (CLEE) and its associations with various health metrics.
  • Divided participants into menopause-positive and menopause-negative groups for analysis.
  • Longer CLEE was associated with lower disability scores and better performance on cognitive tests.
  • Findings included thicker optic nerve head and retinal nerve fiber layer in those with longer CLEE.
  • Menopause-positive women experienced greater brain volume loss compared to menopause-negative women after 12 months.

Cite This Study

Ianniello et al. (2026) studied this question.

synapsesocial.com/papers/69aa6eb1531e4c4a9ff58ea2https://doi.org/10.1016/j.jns.2026.125854
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Also Consider

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