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This is a Quantitative Study study.

September 30, 2025CancersOpen Access

Novel MAML2 Fusions in Human Malignancy

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DNA and RNA sequencing revealed new MAML2 fusions in tumor samples, suggesting implications in gene transcription and genomic instability.

Novel MAML2 fusions were found in human malignancies, particularly with MTMR2, SESN3, CCDC82, and FAM76B.
Among 180,124 samples analyzed, 143 had MAML2 fusions, with novel fusions showing higher fusion burdens compared to known fusions.
The research involved DNA and RNA sequencing on tumor samples submitted to Caris Life Sciences, focusing on aberrant gene transcription.
Findings indicate many novel fusions may result from genomic instability, while ATXN3::MAML2 could be a pathogenic alteration requiring further study.

Komiya et al. (2025) studied this question.

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DNA and RNA sequencing revealed new MAML2 fusions in tumor samples, suggesting implications in gene transcription and genomic instability.