Why the study?
MAML2-related fusions were recently encountered in undifferentiated malignant epithelioid neoplasms that do not fit established pathologic entities.
Design
Clinicopathologic case series
Follow-up
Median 8 months in 4 cases with detailed clinical history
Key result
MAML2 gene rearrangements were identified in seven cases of malignant undifferentiated epithelioid neoplasms, with 3 of 4 followed patients developing distant metastasis.
Authors
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MAML2 fusions mark a novel subset of undifferentiated epithelioid sarcomas; leaves open classification and targeted therapy implications.
Case Report (n=7)
Describes a heterogeneous series of MAML2-rearranged undifferentiated malignant epithelioid neoplasms, expanding the clinicopathologic spectrum of mesenchymal neoplasms with recurrent MAML2 gene rearrangements.
Dermawan et al. (2022) conducted a case report in Malignant undifferentiated epithelioid neoplasms with MAML2 rearrangements (n=7). MAML2 gene rearrangements was evaluated. MAML2 gene rearrangements were identified in seven cases of malignant undifferentiated epithelioid neoplasms, with 3 of 4 followed patients developing distant metastasis.
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