Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 18, 2025American Journal of Dermatopathology

Myxoinflammatory Fibroblastic Sarcoma, Nodular-Necrotizing Variant With Two YAP1::MAML2 Fusions and TRIM24::BRAF Fusion

View Full Paper
Ask AI
Bookmark
Share

Authors

KHKim HarnischBBBeata Bode‐LesniewskaOCObinna Chijioke

Discussion

Loading...

Member takes

Overview

Case report identifies novel yap1::maml2 and trim24::braf fusions in a rare soft tissue neoplasm, suggesting new therapeutic targets.

Key Points

  • Presence of multiple gene fusions indicates significant genetic variability in myxoinflammatory fibroblastic sarcoma, contributing to its complexity in diagnosis.
  • Identification of two yap1::maml2 fusions alongside a trim24::braf fusion points to unique genetic markers that may influence treatment approaches.
  • Histopathologic examination confirmed unique cellular features in a 40-year-old patient, further emphasizing the distinct characteristics of this neoplasm.
  • Findings support the role of advanced sequencing technologies in detecting rare genetic alterations, which may assist in future clinical management of similar cases.

Cite This Study

Harnisch et al. (2025) studied this question.

synapsesocial.com/papers/68af475aad7bf08b1ead4261https://doi.org/10.1097/dad.0000000000003107
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deep sequencing of myxoinflammatory fibroblastic sarcoma2020 · 25 citations
  2. 2Myxoinflammatory Fibroblastic Sarcoma of the Scalp2015 · 7 citations
  3. 3Myxoinflammatory Fibroblastic Sarcoma: A Radiographical, Pathological, and Immunohistochemical Report of Rare Malignancy2015 · 7 citations
  4. 4Malignant undifferentiated epithelioid neoplasms with MAML2 rearrangements: A clinicopathologic study of seven cases demonstrating a heterogenous entity2022 · 20 citations
  5. 5Acral myxoinflammatory fibroblastic sarcomas: are they all low‐grade neoplasms?2007 · 52 citations