Exploration reveals MTHFR gene variations affect folic acid metabolism in hyperhomocysteinemia, suggesting links to NCDs.
Non-communicable diseases (NCDs) remain a leading global health concern, with hyperhomocysteinemia recognized as a contributing metabolic disorder linked to cardiovascular disease, neurodegenerative conditions, and developmental anomalies. This presentation explores the pivotal role of methylenetetrahydrofolate reductase (MTHFR) polymorphisms—particularly C677T and A1298C variants—in disrupting homocysteine metabolism through impaired folate and vitamin B pathways.
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Rina Triana (2025) studied this question.
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