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October 1, 2025Proteoglycan ResearchOpen Access

Decorin Evokes a Pro‐Lysosomal Pathway in Lymphatic Endothelial Cells

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Authors

GPGabriel J. PascalDMDipon Kumar MondalSKSadie Kim

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Overview

Proteomic analysis reveals decorin's role in lysosome pathways in lymphatic cells, highlighting potential cancer targets.

Key Points

  • Decorin triggers pro-lysosomal pathways in lymphatic endothelial cells, enhancing autophagy functions.
  • Notable proteins like Lamp1 and Nedd8 were differentially regulated after decorin treatment, emphasizing their roles.
  • Comprehensive proteomic analysis identified vital protein pathways linked to cancer suppression and lymphangiogenesis.
  • These findings suggest decorin and its regulated proteins could serve as therapeutic targets for cancer treatments.

Cite This Study

Pascal et al. (2025) studied this question.

synapsesocial.com/papers/68dd89e6fe798ba2fc4980c5https://doi.org/10.1002/pgr2.70038
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression2024 · 11 citations
  2. 2Recombinant Human Decorin Normalizes the Active Features of Breast Cancer-Associated Fibroblasts2026
  3. 3Systemic and local decorin levels mirror the clinical course of pancreatic cancer2025
  4. 4Unraveling the significance of decorin in endometriosis development through single cell sequencing and experimental approaches2026
  5. 5Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway2025