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October 1, 2025Hematology ReportsOpen Access

Association of Cognitive Impairment with Reduced Health-Related Quality of Life and Depression Among Survivors of Thrombotic Thrombocytopenic Purpura

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Authors

SSSruthi SelvakumarJYJia YuJMJavier Bolaños Meade

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Overview

Cross-sectional analysis links cognitive impairment with lower health-related quality of life and increased depression in iTTP survivors, suggesting necessary interventions.

Key Points

  • Cognitive impairment is linked to significantly reduced health-related quality of life in iTTP survivors.
  • iTTP survivors had lower mean scores in seven SF-36 domains compared to the reference population.
  • Fluid cognition showed a strong correlation with physical health-related quality of life metrics.
  • Regular mental health screening may help iTTP survivors address depressive symptoms effectively.

Cite This Study

Selvakumar et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc49832bhttps://doi.org/10.3390/hematolrep17050051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term health-related quality of life and mental health in patients with immune thrombotic thrombocytopenic purpura2024 · 3 citations
  2. 2Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura2021 · 13 citations
  3. 3A Qualitative Study on Patient Experience with Signs, Symptoms, and Daily Impacts of Immune Thrombocytopenia2025
  4. 4Multicenter Prospective Pilot Study Identifying Thrombomodulin as a Potential Biomarker for Neurocognitive Outcomes in Immune Thrombotic Thrombocytopenic Purpura2025 · 4 citations
  5. 5The Impact of Hereditary TTP on Psychological Health, Cognition, and Well-Being: A Patient-Reported Outcomes Study2026