Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 31, 2026Open Access

The impact of hereditary TTP on psychological health, cognition, and well-being: a patient-reported outcomes study.

View Full Paper
Ask AI
Bookmark
Share

Authors

ABAzra BorogovacJAJoanne AlbertUniversity of Oklahoma Health Sciences CenterJNJulia NaifehUniversity of Oklahoma Health Sciences Center

Discussion

Loading...

Member takes

Implication

Patient-reported outcomes reveal chronic psychological impact of hereditary TTP on well-being over time, indicating a need for interventions.

Key Points

  • This study aims to evaluate the psychological and cognitive effects of hereditary thrombotic thrombocytopenic purpura (hTTP) on patients.
  • Patients enrolled completed assessments using Patient-Reported Outcomes Measurement Information Systems over three time points.
  • Mean scores were compared to the general US population using t-tests and changes over time were assessed using repeated-measures ANOVA.
  • Literature search was conducted to identify comparison disorders.
  • Patients reported significantly worse scores in fatigue, depression, anxiety, and cognitive function compared to the US population.
  • Scores for positive affect were similar to the general population, but overall well-being was lower in patients compared to those with immune-mediated TTP and other chronic diseases.
  • No significant changes in outcomes were observed over the assessment periods.

Cite This Study

Borogovac et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2ab5783ba022b6fe25ehttps://doi.org/10.48620/98031
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The impact of hereditary TTP on psychological health, cognition, and well-being: a patient-reported outcomes study2026
  2. 2Natural History and Treatment Outcomes of Congenital Thrombotic Thrombocytopenic Purpura: A Retrospective Longitudinal Cohort Study2026
  3. 3Longitudinal characterization of symptoms, healthcare resource utilization, and costs among people with thrombotic thrombocytopenic purpura compared with non-thrombotic thrombocytopenic purpura controls2024
  4. 4Modern management of congenital thrombotic thrombocytopenic purpura (cTTP)2025 · 4 citations
  5. 5Hereditary thrombotic thrombocytopenic purpura associated with recurrent strokes and prominent nervous system involvement in a young Chinese female2024